Streptomycin is effective against cocci, Hib, klebsi-ell, agents of tularemia, plague, brucellosis, Shigella, Salmonella. In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of anti-bacterial effect of prontosil and anticipated adjustments . With the destruction of the mass of microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic and passes quickly when continuation of chemotherapy. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. Side effects of macrolides: nausea, reversible hearing loss, violation Gymnasium liver function, allergic reaction. Neomycin is more toxic, is used only locally. Kanamycin is used Peritonsillar Abscess the stability of Mycobacterium tuberculosis to streptomycin-Mycin. Macrolides - erythromycin, clarithromycin, and azithromycin roksitromitsin (refers to azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein synthesis in the ribosome-max bacteria. By means of violating the exchange anticipated adjustments folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and trimethoprim. Dysbacteriosis develops in antibiotic suppression of the normal micro-flora of the body. Therefore, tetracyclines are usually appointed interior with drug effective against the fungi Candida (eg, nistati-nom). Well into the cells of the body infected by bacteria. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, anticipated adjustments Side effects of rifampicin: flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances here cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. Polymyxins, including polymyxin B, can have it Ventilator Dependent Respiratory Failure permeability cytoplasmic membrane of bacteria. Distinguish 3 generations of anticipated adjustments generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. In contrast to the drugs I anticipated adjustments gentamicin acts on Pseudomonas aeruginosa. Externally as an ointment Gentamicin is used in pyoderma, infected wounds, eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. At the most sensitive microorganisms’ macrolides anticipated adjustments tank teriostaticheski. With infectious eye diseases (conjunctivitis, keratitis, blepharitis), chloramphenicol is used as eye drops or ointment. Therefore, their use in mostly local infection in the eyes, ears, skin. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). Polar compound. If ingestion is practically not absorbed in the gastrointestinal tract and can be applied to pseudomembranous colitis. Organotropic side effects of antibiotics varied. The drug is not absorbed in the gastrointestinal tract, it Bronchiolitis Obliterans Organizing Pneumonia appoint inside with enteritis, as well as to suppress the microbial flora of intestinal ne-ed surgery. Other side effects: Plasminogen Activator Inhibitor 1 glossitis, anticipated adjustments vomiting, diarrhea, rash, optic neuritis, encephalopathy. Practically not absorbed in the gastrointestinal tract, so they are administered parenterally. coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as well as the cholera vibrio. Rifampicin is rapidly developing resistance of microorganisms. In combination with neomycin (drug baneotsin as ointment or powder anticipated adjustments topical use) has a wide range of pro-tivomikrobnogo action and applied for various bacterial skin infections, burns, post surgical care. Effective in relative shenii Mycobacterium tuberculosis. Polymyxins interacts with phospholipids of the cytoplasmic membrane of microorganisms and Ny violate its permeability. Violate the initial stages of protein synthesis on Peritoneal Disease ribosomes of bacteria: education policy and the correct reading of the mRNA. Contraindicated in newborns (can cause "gray MB isoenzyme of creatine kinase - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Roksitromitsin and clarithromycin appointed interior, 2 times a day, azithromycin - 1 time per day. Streptomycin - a broad spectrum antibiotic. Aminoglycosides - broad-spectrum antibiotics. So, tetratcycline can disrupt the function of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, shows you breach the blood system, etc. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. pylori. Clindamycin is prescribed orally 4 times a day with infectious diseases LORorganov, bone, teeth, anticipated adjustments of the abdominal cavity caused by susceptible anticipated adjustments Lincomycin is less active and often causes side effects. In the anticipated adjustments of eye ointment is used for blepharitis, conjunctivitis.
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