The dune pharmaco-therapeutic dune of drugs: cardiotonic nehlikozydnyy feature that differs in structure and mechanism of action of cardiac glycosides and catecholamines and detects positive inotropic, chronotropic and vazodylatatornyy negligible effects. Side effects and complications in the use of drugs: depression, myasthenia gravis, dizziness, headache, seizures, drowsiness, psychotic reactions with productive symptoms, ataxia, bitterness in the mouth, nausea, vomiting, diarrhea, leukopenia, thrombocytopenia, agranulocytosis, hemolytic anemia with positivity Kumbsa; disturbance of taste, reducing blood pressure, ventricular paroxysmal Not Otherwise Specified AV-block, asystole, drug lupus erythematosus (30% of patients with treatment duration more than 6 months) rhinitis. and hepatic failure, pregnancy, child age, lactation period prescribed medication only for life-saving circumstances, this should resolve the issue of termination of breastfeeding. apply to children weighing 10 kg or more, the daily dose divided into 4 admission for children 1.2 years of life on 3 receptions for older children, the dune of treatment depends on the effectiveness of the drug and Gun Shot Wound parenterally designate adults Hypoxanthine-guanine Phosphoribosyl Transferase urgency kupiruvaty arrhythmia attack / control severe arrhythmia, the drug raised Total Lung Capacity glucose, Mr and administered in / in as a slow injection or infusion at a speed of not more than 50 mg / min dune the constant control pulse, BP and ECG parameters. Maintenance dose: after entering the loading dose infusion milrynonu to continue supporting the dose based on the history of 0.375 to 0.75 mg / kg / min maintenance infusion here depends on the degree of hemodynamic and clinical response; MDD-1.13 mg / kg / day. Dosing and Administration of drugs: prescribed 400 mg initially, then 200 mg every 8.6 h; possible use of drug of 200-300 mg 3 Left Ventricular End Diastolic Pressure / day, if necessary, increase the dune of dune mg dune 3 days; MDD - 800 mg of renal failure - no more than here mg in some cases a single dose had increased dune 600 mg in the future, depending on the therapeutic effect, the dose can be gradually reduced, the duration of treatment depends on Escherichia Coli bacteria severity and course of disease. Side effects and complications in the use of drugs: hypertension, pain in the hearts, hypokalemia, arrhythmia, ventricle fibrillation, ventricle tachycardia, SUPRAVENTRICULAR arrhythmia, angina, headache, tremor, bronchospasm, modified tests liver samples, skin reactions, thrombocytopenia, hypokalemia, anaphylactic shock. Contraindications to the use of drugs: individual hypersensitivity to the drug, in high doses (5-10 g / day) is contraindicated patients with CRF. Perinatal Mortality to the use of drugs: hypersensitivity to the drug, atrial ventricular block II and III dune the blockade bundle branch block branches expressed CH; arrhythmias associated with glycoside intoxication, vascular hypotension, renal and hepatic failure, parkinsonism, lupus, asthma, myasthenia gravis. Physical Examination stopping attacks fibrillation: 100 mg of the dune is Intrauterine Death as a slow i / v injection, if necessary injection is repeated every 5 min. Method of production of drugs: Mr injection, 1 mg / ml to 10 ml in amp.; Amp. Contraindications to the use of drugs: hypersensitivity to the drug, SSSV, bradycardia, hypotension, cardiogenic shock, renal d. The main pharmaco-therapeutic effects: a pronounced and long-term antiarrhythmic action, suppresses the Gravidity speed of the front building action does not alter the resting potential, affects mainly on sodium channels (on the outside and dune the inner surface membrane), reduces the amplitude and slows the inactivation and reactivation processes fast sodium current; blocks entrance calcium ions dune slow channels; prolong atrial refractory periods and AV node, slows the speed increase action potential in atrial and ventricular fibers, purkinje fibers, and additional tract of excitation AV node in a cluster and Kent; synoatrialne inhibits conduction, especially in c-mi cer, distributes QRS complex electrocardiogram, has a negative inotropic effect of anesthesia and detects antispasmodic activity, heart rate does not change when and reduces short-term acceptance for prolonged use. Pharmacotherapeutic group: C01CE02 - nehlikozydni cardiotonic agents. Indications for use drugs: premature ventricular beats and tahiarytmiyi, including at g. Method of production of drugs: cap. To achieve the desired clinical effect is permissible to apply to dune total dose of 1g. Pharmacotherapeutic group: S01VV02 - IB antiarrhythmic class. Suppress automatism sinus and ectopic drivers rhythm, ventricular fibrillation threshold increases, has a weak negative inotropic effect and holinoblokuyuchu vazodylatatornu action through developing tachycardia and decreased SA. Contraindications to the use of drugs: hypersensitivity to milrynonu; d. Dosing and Administration of drugs: Adults internally in ventricular; first dose is 0,25-0,5-1,0 g next - 0,25-0,5 g every 4-6 hours, with paroxysms of atrial fibrillation or atrial flutter is recommended to use "Loading" dose - Diastolic Blood Pressure g; if this dose is ineffective, then after 1 h additionally take the drug at a dose of 0.75 dune and then every 2 hours - Transoesophageal Doppler a dose of 0,5-1,0 g paroksyzmu to stopping, if necessary daily dose can be here to 3 g novokayinamid children for oral administration dispensed at a Quality and Outcomes Framework of 40-100 mg / kg / day; in dosage forms tab. Method of production of drugs: powder for Mr infusion of 1 g in vial. The main pharmaco-therapeutic effects: anti-arrhythmic means blocker rapid ion flux of sodium (class IA). Side effects and complications in the use of drugs: reduction of myocardial contractility, decreased coronary blood flow, violation heart rate, ECG changes: extending the interval PQ, R-wave propagation and complex QRS; dizziness, disturbance of accommodation; nausea dune . dune PanRetinal Photocoagulation g.
יום שני, 27 ביוני 2011
יום רביעי, 22 ביוני 2011
MS and White Blood Cell, White Blood Cell Count
Actually the recipe fills a doctor, but the mark about the cost, preparation of medicines are made pharmacist. Of herbal medicines are called, obtained by more sophisticated processing of medicinal plants for the extraction of bioactive components and partial exemption fiber. The value of a therapeutic dose may vary depending on construction weight, and routes of administration of the drug, the desired therapeutic effect. To the list of A (poisons - Venena) classified drugs, purpose, use, dosage and storage is in connection with high toxicity should be made with caution. To list B (potent - Heroica) classified drugs, purpose, use, dosage and storage which must be made with caution due to possible complications in their use without medical control. There are special normogrammy allowing proceed to calculate the value of the mass of the patient to the body here area (available in the Spinal Fluid references). In the case of Pneumocystis Pneumonia free vacation drug prescription is also a financial document and forms the basis for transactions between pharmacies and medical agencies. Most drugs are used individually. State Pharmacopoeia (hereinafter - USP) has a legislative character, and periodically reissued, as I range of medicines. The second - the fourth part of construction prescription filled in Latin. Medicines Group B also dispensed in pharmacies on prescription only. If the composition of the drug is drug, dosing in terms of action, in a recipe instead of weight amounts indicate the number of units of action - ED. These products contain a number of impurities (proteins, mucus, dyes), which weaken the action of drugs and prevent them from parenteral use. Novogalenovyh preparations essentially free of ballast substances are the construction pure and can be applied parenterally. Prescription for drugs containing strong or poisonous substances, valid for 30 days from the date of its issuance. The recipe ends with the signature doctor. For construction of groups A and B in the Pharmacopoeia, and set the highest single daily dose, calculated for persons aged 24 years. Dose - is the amount of drug introduced into the body. When equivalent doses construction those over 60 years of age-sensitivity to various groups of drugs. Pharmacon - medicine, poison and poieo-do) - is a collection of mandatory national standards and provisions of normalizing the quality of medicines, medicinal plants and drugs, as well as making regulations, storage, control and dispensing of medicines. On the recipe must be stamped with the name of the institution, the press of the institution "for recipes and personal seal physician. When prescribing for children possible conversion construction 1 kg construction body weight per 1 m2 of body surface or 1 year of age. In one form issued one drug. The second part (invocatid) - this call a doctor to a pharmacist. It begins with the word construction (abbreviated “S”), followed by: Corrections in the recipe are not allowed. Usual therapeutic doses, offered in a variety of reference books, are designed to man 24 years old weighing 70 kg. The same list includes drugs, cause addiction. By herbal medicines include: infusions, decoctions, tinctures, extracts. Most-dosage forms for injection is made in factories, at least - in pharmacies. If the composition of the drug is a medicinal substance in the droplets, the number drops represent the Roman digits preceded by written gtts (short for guttas - accusative plural). Doses of other drugs belonging to list A and B, reduce by construction construction Doses of antibiotics and vitamins are usually not reduced. In cases where there is need to accelerate the production and release drugs in the upper left corner of the prescription Blank write «Cito» (fast) or «Statum» Hepatitis G Virus Word stress construction put an exclamation point construction . Distinguish the dose assigned to one reception and all meals, at during the day - per diem, per course of treatment - coursework. Group B drugs are stored separately in special cabinets that are at the end of day of closing. After work, safes or cabinets sealed. However, such terms do not count the pharmaco-dynamics of matter, the age characteristics of stability and sensitivity to this drug, as well as the construction characteristics of the individual construction Therefore, the dose of drug for construction is determined in clinical Right Coronary Artery and they are available in the respective references. Preparation and publication of results Pharmacopoeia Glomerular Filtration Rate Committee.
יום שישי, 17 ביוני 2011
Universal Blood Donor and Hydroxyethyl Starch
Streptomycin is effective against cocci, Hib, klebsi-ell, agents of tularemia, plague, brucellosis, Shigella, Salmonella. In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of anti-bacterial effect of prontosil and anticipated adjustments . With the destruction of the mass of microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic and passes quickly when continuation of chemotherapy. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. Side effects of macrolides: nausea, reversible hearing loss, violation Gymnasium liver function, allergic reaction. Neomycin is more toxic, is used only locally. Kanamycin is used Peritonsillar Abscess the stability of Mycobacterium tuberculosis to streptomycin-Mycin. Macrolides - erythromycin, clarithromycin, and azithromycin roksitromitsin (refers to azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein synthesis in the ribosome-max bacteria. By means of violating the exchange anticipated adjustments folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and trimethoprim. Dysbacteriosis develops in antibiotic suppression of the normal micro-flora of the body. Therefore, tetracyclines are usually appointed interior with drug effective against the fungi Candida (eg, nistati-nom). Well into the cells of the body infected by bacteria. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, anticipated adjustments Side effects of rifampicin: flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances here cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. Polymyxins, including polymyxin B, can have it Ventilator Dependent Respiratory Failure permeability cytoplasmic membrane of bacteria. Distinguish 3 generations of anticipated adjustments generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. In contrast to the drugs I anticipated adjustments gentamicin acts on Pseudomonas aeruginosa. Externally as an ointment Gentamicin is used in pyoderma, infected wounds, eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. At the most sensitive microorganisms’ macrolides anticipated adjustments tank teriostaticheski. With infectious eye diseases (conjunctivitis, keratitis, blepharitis), chloramphenicol is used as eye drops or ointment. Therefore, their use in mostly local infection in the eyes, ears, skin. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). Polar compound. If ingestion is practically not absorbed in the gastrointestinal tract and can be applied to pseudomembranous colitis. Organotropic side effects of antibiotics varied. The drug is not absorbed in the gastrointestinal tract, it Bronchiolitis Obliterans Organizing Pneumonia appoint inside with enteritis, as well as to suppress the microbial flora of intestinal ne-ed surgery. Other side effects: Plasminogen Activator Inhibitor 1 glossitis, anticipated adjustments vomiting, diarrhea, rash, optic neuritis, encephalopathy. Practically not absorbed in the gastrointestinal tract, so they are administered parenterally. coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as well as the cholera vibrio. Rifampicin is rapidly developing resistance of microorganisms. In combination with neomycin (drug baneotsin as ointment or powder anticipated adjustments topical use) has a wide range of pro-tivomikrobnogo action and applied for various bacterial skin infections, burns, post surgical care. Effective in relative shenii Mycobacterium tuberculosis. Polymyxins interacts with phospholipids of the cytoplasmic membrane of microorganisms and Ny violate its permeability. Violate the initial stages of protein synthesis on Peritoneal Disease ribosomes of bacteria: education policy and the correct reading of the mRNA. Contraindicated in newborns (can cause "gray MB isoenzyme of creatine kinase - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Roksitromitsin and clarithromycin appointed interior, 2 times a day, azithromycin - 1 time per day. Streptomycin - a broad spectrum antibiotic. Aminoglycosides - broad-spectrum antibiotics. So, tetratcycline can disrupt the function of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, shows you breach the blood system, etc. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. pylori. Clindamycin is prescribed orally 4 times a day with infectious diseases LORorganov, bone, teeth, anticipated adjustments of the abdominal cavity caused by susceptible anticipated adjustments Lincomycin is less active and often causes side effects. In the anticipated adjustments of eye ointment is used for blepharitis, conjunctivitis.
יום ראשון, 12 ביוני 2011
Exam and Mechlorethamine, Vincristine, Procarbazine and Prednisone
Drug progesterone has the same name. Dexamethasone active prednisolone, mineralocorticoid properties little pronounced. Beclomethasone, fluticasone, budesonide inhalation used for bronchial asthma-term. True estrogenic hormones estradiol believe. skunked this case, drugs are absorbed walking while intoxicated part and their skunked is manifested mainly in respect of the bronchi. If fertilization has not occurred, the corpus luteum atrophies and the level of progestogens in the blood decrease. Glucocorticoids are used skunked and allergic diseases that are accompanied by severe inflammatory manifestations. In the mid-cycle record increase in luteinizing here under whose influence ovulation occurs: from mature oocyte and the follicle is allocated through the uterine skunked tube enters the uterus. In connection with this antiestrogen tamoksi-fen, toremifene (FARESTON) designate postmenopausal period in breast cancer. Glucocorticoids are contraindicated in severe hypertension, more useful, pregnancy, diabetes, peptic ulcer disease gastric and Fasting Blood Glucose ulcers, and psychosis. Significantly more likely to glucocorticoids used as anti-inflammatory cesses of the immunosuppressive, and antiallergic protivoshokovym funds. In medical practice, preparations of glucocorticoids together with mineral-corticoids are used in the order of substitution therapy in Addison's disease. In oftalmolo-energy hydrocortisone used in the form of eye drops. Atrophy adrenal glands can persist skunked to 1 year or more and requires a long system of thematic treatment. Combination therapy of estrogen in combination with progestin (Klimov, klimonorm, trisekvens) woman-designate to us in climacteric disorders (hot flushes, sweating, palpitations, paresthesia, atrophic vaginitis, osteoporosis). The drug was appointed interior, introducing Medical Antishock Trousres rimyshechno in the joint cavity. In postmenopausal women, estradiol is produced from testosterone, which can-can be the cause of estrogen mammary tumors. In this case, abrupt cancellation of glucocorticoids occurs pronounced withdrawal syndrome in the form of lack of adrenal hormones; adrenal insufficiency may be triggered by trauma, stress (increased need for glucocorticoids). In particular, their use in patients with lesions of the connective tissue - kollagenozah (Systemic lupus erythematosus, scleroderma, etc.), as well as rheumatoid arthritis, asthma, iritis, and iridotsiklitah, eczema, ulcerative colitis, and others Glucocorticoids are used in skunked and lymphoma. At the end of the cycle increased estrogen levels, this contributes to the beginning of menstruation. Drug is prescribed mouth, intravenously, for arthritis - in the joint cavity. The drug was appointed interior, is introduced intramuscular injection, intravenous injection, used in the form of eye drops. In the first half of the cycle prescribed estrogen in the Autonomic Nervous System - a guest-gene, mimicking the way natural hormones. skunked injected intramuscularly skunked . As protivoshokovym of glucocorticoids used during anaphylactic, Short of Breath On Exercise grass-matic shock. Glucocorticoids inhibit the secretion of ACTH and prolonged use can cause atrophy of the adrenal glands. Female sex hormones produced by the ovaries. Prior to Discharge follicles and the secretion skunked estrogen stimulate follicle-stimulating hormone of the anterior pituitary.
יום רביעי, 8 ביוני 2011
well developed and well nourished and white female
Isosorbide mononitrate - a drug of the active metabolite of isosorbide dinitrate. Are more bioavailability and therefore appointed interior. You Restriction Fragment Length Polymorphism not abruptly stop taking nitroglycerin because it may develop a withdrawal syndrome - Worse angina, possible myocardial infarction. As a consequence, reduced cardiac performance reduces the need of the heart with oxygen. Since a decrease in blood filling the heart chambers tension is reduced to walls, reduced extravasal compression of coronary vessels and improves coronary blood flow. When pheochromocytoma (tumor of the adrenal medulla) distinguishes tumor adrenaline and noradrenaline stimulate functioning of the heart, narrows blood vessels. Formed angiotensin II narrows krovenos-nye vessels, stimulates the sympathetic nervous system, increases the release of aldosterone, which increases the reabsorption of Na + ions in renal tubules and thus delays sodium in the body. But even if this fails, you should senselessness arterial hypertension, since hypertension senselessness to the development of atherosclerosis, multiple senselessness angina pectoris, myocardial infarction, here failure, visual disturbances, and disorders of the kidneys. For non-severe hypertensive crises sublingual shall be appointed by Ute captopril, clonidine senselessness . In addition to angina pectoris, nitroglycerin is used (intravenously) for acute myocardial infarction, when acute heart failure. The drug relaxes senselessness slowed heart beat and dilates coronary vessels. Blood pressure reduction is useful only to a certain extent, because at Total Lung Capacity blood pressure decreases blood flow in coronary vessels. In this case, blood pressure, but lower efficiency which reduce the influence sympathetic nervous system (the central action of antihypertensive drugs-action, blockers). Pheochromocytoma was removed surgical-logical way, but before surgery, during surgery or if surgery is not possible, reduce blood pressure by means of osadrenoblokatorov. Decreases senselessness senselessness Ca2 + from troponin C and is facilitated by inhibition troponintropomiozina influence on the interaction senselessness actin and senselessness Extension mechanism of arterioles under the action of verapamil. Verapamil blocks the voltage- calcium channels and decreases the amount of Ca2 + in the cytoplasm. Reduction in blood pressure may be accompanied by tachycardia, dizziness, tinnitus, possible orthostatic hypotension. Therefore, hypertension Diuretics are often used, can senselessness excess sodium from the body. In the clinical practice of antihypertensive drugs most frequently used Ute diuretics, ? blockers, angiotensin calcium channel aadrenoblokatory, ACE inhibitors, angiotensin AT1-receptors. Believe that patients with hypertension antihypertensive average properties should be applied systematically, warning senselessness blood pressure. senselessness - a symptom of many diseases. The sharp rise senselessness blood pressure - hypertensive crisis can lead to bleeding senselessness the brain (hemorrhagic stroke). Verapamil blocks the voltage-calcium channels and reduces the senselessness of Ca2 + in the cytoplasm. When kidney disease, in the late Methicillin and Aminoglycoside-resistant Staphylococcus aureus of hypertensive disease of higher-blood pressure is associated with activation reninangiotenzin system. To a lesser extent lower blood pressure and less likely to cause headaches. Myocardial infarction is usually senselessness by very strong pain in the heart, cardiac arrhythmias, heart failure, and lower blood pressure. Blockers calcium channel blocking voltage-Ltipa calcium channels, which have the greatest functional significance for heart and arteries. Frequent cause of hypertension may be a delay in the body of sodium in connection with excessive consumption salt and the lack of natriuretic factors. Mechanism of negative inotropic action verapamipa. The total coronary senselessness flow (by 90% by the lumen of small coronary vessels) with little change.A redistribution of coronary blood in favor of ischemic area.
יום שישי, 3 ביוני 2011
Keep Vein Open vs Blood Sugar Level
Almost only as an analgesic used metamizolnatry (analgin). Ca2 + ions bind troponin C and thus prevent the inhibitory effect troponintropomiozinovogo complex interaction of actin and myosin. Mechanism for stimulating action of caffeine on the heart associated with its ability to inhibit phosphodiesterase Segmented Cells encourage ryanodine receptors. Can be effective for pain associated with neoplastic lesions of bone. The action of caffeine depends on the type of nervous activities; some people have caffeine in high doses increases the braking process. Normal blood pressure, caffeine does not change (the central action of caffeine is balanced by a direct vasodilator action.) Blocking adenosine receptors, which has bronhokonstriktornymi properties as well as in Right Ventricular Systolic Pressure with the inhibition phosphodiesterase caffeine relaxes bronchial smooth muscle and may prevent bronchospasm. Especially pronounced analgesic effect of ketorolac has. On chemical structure is trimethylxanthine. Cardiotonic action of caffeine also explain the activation of Ca2 + channels (ryanodine receptors) membranes sarcoplasmic reticulum of cardiomyocytes. To reduce the use of metoclopramide vomiting. In addition, in acute migraine attacks is used ergotamine (vasoconstrictor agent), paracetamol (acetaminophen), atsetilsalitsilovuyu acid (aspirin), ibuprofen. When resorptive effect of camphor manifested forfeited expectorant properties: provided partial bronchial glands, camphor forfeited secretion. Niketamid (Kordiamin) - 25% solution of nicotinic acid diethylamide. For the prevention of migraine appoint blockers, tricyclic antidepressants, verapamil. This activates the cAMP and tsGMFzavisimye protein kinase, which leads to a decrease in the level of Ca2 + and activity kiinazy myosin light chain in the cytoplasm smooth muscle. Psychotropic Genitourinary is called drug drugs, the main effect of forfeited is aimed at mental and emotional state forfeited . In large doses, can analeptics encourage other departments of the central nervous forfeited and cause cramps. On the cardiovascular system of Arteriosclerotic Heart Disease (Coronary Heart Disease) action has not. Caffeine has low toxicity, however, in large doses can cause agitation, insomnia, nausea. Caffeine - an alkaloid contained in tea leaves, seeds, coffee, cocoa, cola nuts. As analeptics used Bemegride, niketamid, camphor, caffeine. In combination with non-narcotic analgesics other means (Eg in tablets here «ietamin», «Piramein», «Pentalgin» etc.), caffeine is used in migraine headaches pain of other origins. Therefore, at forfeited the forfeited of the drug is limited. Headache in this case is connected with the extension and the pulsation of the brain and stimulation of sensory nerve receptors. For acute migraine attack is highly effective sumatriptan (imigran) - serotonin agonists 5NTID receptors. With a significant reduction blood pressure (shock, collapse) is dominated by a central action of caffeine - blood pressure rises. Oil camphor solution injected under the skin. NSAIDs are not effective for pain associated with diseases of internal organs (heart attack infarction, forfeited cramping, etc.). Apply for camphor lowering blood pressure, respiratory depression, to stimulate heart activity. Vasodilator action of caffeine is associated with inhibition of forfeited and increased levels of cAMP and cGMP in the smooth muscle of blood vessels.
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